Diabetes causes metabolic and physiologic abnormalities in the retina, and these changes
suggest a role for inflammation in the development of diabetic retinopathy. These changes …

Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies
have established an inverse relationship between the ingestion of omega-3 fatty acids [C 20 …

OBJECTIVE—This study determined the effects of high glucose exposure and cytokine
treatment on generation of reactive oxygen species (ROS) and activation of inflammatory …

Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …

In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by
unknown mechanisms. The steroid hormone aldosterone acts by binding to the …

purpose. The receptor for advanced glycation end products (AGEs) has been implicated in
the pathogenesis of diabetic complications. This study was conducted to characterize the …

purpose. Docosahexaenoic acid (DHA 22: 6n3), the principal n3-polyunsaturated fatty acid
(PUFA) in the retina, has been shown to have a pronounced anti-inflammatory effect in …

Obesity plays a pivotal role in the development of low-grade inflammation. Dietary fatty acids
are important modulators of inflammatory responses. Saturated fatty acids (SFA) and n-6 …

Chronic hyperglycemia (HG)-associated reactive oxygen/nitrogen species (ROS/RNS)
stress and low grade inflammation are considered to play critical roles in the development of …

Diabetic retinopathy (DR) affects over 93 million people worldwide and is the number one
cause of blindness among working age adults. These indicators coupled with the projected …