Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and
activities of transcriptional factors involved in both cancer initiation and progression through …

Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin
remodeling and have crucial roles in numerous biological processes, largely through their …

The interest in histone deacetylase (HDACa) inhibitors began almost 30 years ago during
some studies designed to understand why dimethyl sulfoxide (DMSO) caused terminal …

Acute myeloid leukemia (AML) is a heterogenous disease with outcomes dependent upon
several factors, including patient age, karyotype, mutational status, and comorbid conditions …

Epigenetics is rising to prominence in biology as a mechanism by which environmental
factors have intermediate-term effects on gene expression without changing the underlying …

Histone deacetylase (HDAC) inhibitors are a new group of anticancer agents that have a
potential role in the regulation of gene expression, induction of cell death, apoptosis and cell …

The recently approved drugs 5-azacitidine (5AC) and 5-aza-2′-deoxyazacytidine (DAC)
are in wide clinical use for the treatment of myelodysplastic syndrome (MDS) of all types and …