Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than
half of the over 65 population. In the past, OA was considered a wear and tear disease …

Abstract Purpose of Review Articular chondrocytes are exclusively responsible for the
turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important
factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses …

Objective The aim of this study was to characterize the genome‐wide DNA methylation
profile of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis …

Osteoarthritis (OA) is the most common form of arthritis, is the leading cause of impaired
mobility in the elderly, and accounts for more than a third of chronic moderate to severe pain …