Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

Pediatric sepsis is a great threat to death worldwide. However, the pathogenesis has not
been clearly understood until now in sepsis. This study identified differentially expressed …

Gene transcription is governed by epigenetic regulation that is essential for the pro-
inflammatory mediators surge following pathological triggers. Acute lung injury (ALI) is …

Objectives Expound upon priorities for basic/translational science identified in a recent
paper by a group of experts assigned by the Society of Critical Care Medicine and the …

Sepsis is characterized by dysregulated gene expression, provoking a hyper-inflammatory
response occurring in parallel to a hypo-inflammatory reaction. This is often associated with …

Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host
response to infection. The presence of oxidative stress and inflammatory mediators in sepsis …

The function of histone methyltransferase enhancer of zeste homolog 2 (EZH2) in sepsis
remains unknown. We reported here that the expression of EZH2 and H3K27me3 was …

A critically ill polytrauma patient is one of the most complex cases to be admitted to the
intensive care unit, due to both the primary traumatic complications and the secondary post …

Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to
determine the expression and function of Tet2 in macrophages upon exposure to …