Clinical trials in acute respiratory distress syndrome: challenges and opportunities
MA Matthay, DF McAuley, LB Ware - The Lancet Respiratory …, 2017 - thelancet.com
This year is the 50th anniversary of the first description of acute respiratory distress
syndrome (ARDS). Since then, much has been learned about the pathogenesis of lung …
syndrome (ARDS). Since then, much has been learned about the pathogenesis of lung …
Prevention of complications in the cardiac intensive care unit: a scientific statement from the American Heart Association
CB Fordyce, JN Katz, CL Alviar, C Arslanian-Engoren… - Circulation, 2020 - Am Heart Assoc
Contemporary cardiac intensive care units (CICUs) have an increasing prevalence of
noncardiovascular comorbidities and multisystem organ dysfunction. However, little …
noncardiovascular comorbidities and multisystem organ dysfunction. However, little …
Effect of dexamethasone on days alive and ventilator-free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX …
Importance Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019
(COVID-19) is associated with substantial mortality and use of health care resources …
(COVID-19) is associated with substantial mortality and use of health care resources …
Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study
M Botta, AM Tsonas, J Pillay, LS Boers… - The lancet Respiratory …, 2021 - thelancet.com
Background Little is known about the practice of ventilation management in patients with
COVID-19. We aimed to describe the practice of ventilation management and to establish …
COVID-19. We aimed to describe the practice of ventilation management and to establish …
Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts
A Serpa Neto, RO Deliberato, AEW Johnson… - Intensive care …, 2018 - Springer
Purpose Mechanical power (MP) may unify variables known to be related to development of
ventilator-induced lung injury. The aim of this study is to examine the association between …
ventilator-induced lung injury. The aim of this study is to examine the association between …
Effect of a low vs intermediate tidal volume strategy on ventilator-free days in intensive care unit patients without ARDS: a randomized clinical trial
FD Simonis, AS Neto, JM Binnekade, A Braber… - Jama, 2018 - jamanetwork.com
Importance It remains uncertain whether invasive ventilation should use low tidal volumes in
critically ill patients without acute respiratory distress syndrome (ARDS). Objective To …
critically ill patients without acute respiratory distress syndrome (ARDS). Objective To …
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted …
Purpose The optimal ventilatory settings in patients after cardiac arrest and their association
with outcome remain unclear. The aim of this study was to describe the ventilatory settings …
with outcome remain unclear. The aim of this study was to describe the ventilatory settings …
Epidemiology, mechanical power, and 3-year outcomes in acute respiratory distress syndrome patients using standardized screening. An observational cohort study
KKS Parhar, K Zjadewicz, A Soo, A Sutton… - Annals of the …, 2019 - atsjournals.org
Rationale: Limited data on the epidemiology of acute respiratory distress syndrome (ARDS)
using a standardized screening program exist. Objectives: To describe the population-based …
using a standardized screening program exist. Objectives: To describe the population-based …
Risk factors and outcomes for airway failure versus non-airway failure in the intensive care unit: a multicenter observational study of 1514 extubation procedures
Background Patients liberated from invasive mechanical ventilation are at risk of extubation
failure, including inability to breathe without a tracheal tube (airway failure) or without …
failure, including inability to breathe without a tracheal tube (airway failure) or without …
Respiratory tract dysbiosis is associated with worse outcomes in mechanically ventilated patients
GD Kitsios, H Yang, L Yang, S Qin, A Fitch… - American journal of …, 2020 - atsjournals.org
Rationale: Host inflammatory responses have been strongly associated with adverse
outcomes in critically ill patients, but the biologic underpinnings of such heterogeneous …
outcomes in critically ill patients, but the biologic underpinnings of such heterogeneous …