IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Background Patients from ethnic minority groups are disproportionately affected by
Coronavirus disease (COVID-19). We performed a systematic review and meta-analysis to …

Introduction Increased age has been reported to be a factor for COVID-19 severe outcomes.
However, many studies do not consider the age dependency of comorbidities, which …

Background and aims The ongoing COVID-19 pandemic is disproportionately affecting
patients with comorbidities. Therefore, thorough comorbidities assessment can help …

Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

Background This study applies an umbrella review approach to summarise the global
evidence on the risk of severe COVID-19 outcomes in patients with pre-existing health …

Objectives We conducted a systematic literature review and meta-analysis of observational
studies to investigate the association between diabetes, hypertension, body mass index …

It has been reported that corticosteroid therapy was effective in the management of severe
acute respiratory syndrome (SARS) and the Middle East Respiratory Syndrome (MERS) …

Background There is accumulating evidence for an overly activated immune response in
severe COVID-19, with several studies exploring the therapeutic role of immunomodulation …

Neutrophil extracellular traps (NETs), built from mitochondrial or nuclear DNA, proteinases,
and histones, entrap and eliminate pathogens in the course of bacterial or viral infections …