Single-molecule super-resolution microscopy has developed from a specialized technique
into one of the most versatile and powerful imaging methods of the nanoscale over the past …

Optical microscopy is widely used to visualize fine structures. When applied to bioimaging,
its performance is often degraded by sample-induced aberrations. In recent years, adaptive …

Single-molecule localization microscopy in a typical wide-field setup has been widely used
for investigating subcellular structures with super resolution; however, field-dependent …

Cryopreservation of tissues and organs can bring transformative changes to medicine and
medical science. In the past decades, limited progress has been achieved, although …

Imaging of both the positions and orientations of single fluorophores, termed single-
molecule orientation-localization microscopy, is a powerful tool for the study of biochemical …

Specimen-induced aberration has been a major factor limiting the imaging depth of single-
molecule localization microscopy (SMLM). Here, we report the application of label-free …

Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …

Distance measurements are commonly performed by phase detection based on a lock-in
strategy. Super-resolution fluorescence microscopy is still striving to perform axial …

Fluorescence microscopes are indispensable to biology and neuroscience. The need for
recording in freely behaving animals has further driven the development in miniaturized …

Immunolabeling and autoradiography have traditionally been applied as the methods-of-
choice to visualize and collect molecular information about physiological and pathological …