[HTML][HTML] Development and recent advancement in microfluidics for point of care biosensor applications: A review
Capillaries are small microscopic channels found in nature predominantly. These flow blood
in animals and food, water and nutritions in plants. Mimicking these capillaries scientist …
in animals and food, water and nutritions in plants. Mimicking these capillaries scientist …
Hypoxia and free radicals: role in tumor progression and the use of engineering-based platforms to address these relationships
A Hielscher, S Gerecht - Free Radical Biology and Medicine, 2015 - Elsevier
Hypoxia is a feature of all solid tumors, contributing to tumor progression and therapy
resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia …
resistance. Through stabilization of the hypoxia-inducible factor 1 alpha (HIF-1α), hypoxia …
[HTML][HTML] An integrated microfluidic concentration gradient generator for mechanical stimulation and drug delivery
Mechanical stimuli, including fluid shear stress, osmotic pressure gradient, and extracellular
matrix stiffness, significantly affect cellular interactions with drugs in biological structures …
matrix stiffness, significantly affect cellular interactions with drugs in biological structures …
[HTML][HTML] Fluid shear stress induces EMT of circulating tumor cells via JNK signaling in favor of their survival during hematogenous dissemination
Tumor cells metastasize to distal organs mainly through hematogenous dissemination,
where they experience considerable levels of fluid shear stress. Epithelial–mesenchymal …
where they experience considerable levels of fluid shear stress. Epithelial–mesenchymal …
[HTML][HTML] Mechanics and actomyosin-dependent survival/chemoresistance of suspended tumor cells in shear flow
Tumor cells disseminate to distant organs mainly through blood circulation in which they
experience considerable levels of fluid shear stress. However, the effects of hemodynamic …
experience considerable levels of fluid shear stress. However, the effects of hemodynamic …
[HTML][HTML] Circulating tumor cells: Towards mechanical phenotyping of metastasis
During cancer progression, metastatic dissemination accounts for∼ 90% of death in
patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through …
patients. Metastasis occurs upon dissemination of circulating tumor cells (CTC) through …
Fluid shear stress regulates the survival of circulating tumor cells via nuclear expansion
Distant metastasis mainly occurs through hematogenous dissemination, where suspended
circulating tumor cells (CTCs) experience a considerable level of fluid shear stress. We …
circulating tumor cells (CTCs) experience a considerable level of fluid shear stress. We …
[HTML][HTML] A microfluidics-based wound-healing assay for studying the effects of shear stresses, wound widths, and chemicals on the wound-healing process
Collective cell migration plays important roles in various physiological processes. To
investigate this collective cellular movement, various wound-healing assays have been …
investigate this collective cellular movement, various wound-healing assays have been …
Potential therapeutic targets of resveratrol in the prevention and treatment of pulmonary fibrosis
Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases,
which are characterized by increased alveolar wall thickness, excessive scarring, and …
which are characterized by increased alveolar wall thickness, excessive scarring, and …
Bioink formulations to ameliorate bioprinting-induced loss of cellular viability
Extrusion bioprinting, the most affordable and convenient bioprinting modality, is also
associated with high process-induced cell deaths. Mechanical stresses on the cells during …
associated with high process-induced cell deaths. Mechanical stresses on the cells during …