Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Challenges in liver cancer and possible treatment approaches

D Anwanwan, SK Singh, S Singh, V Saikam… - Biochimica et Biophysica …, 2020 - Elsevier
Globally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth.
Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor …

The role of polyphenols in overcoming cancer drug resistance: A comprehensive review

P Maleki Dana, F Sadoughi, Z Asemi… - Cellular & molecular …, 2022 - Springer
Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target

A Ghelli Luserna di Rorà, C Cerchione… - Journal of Hematology & …, 2020 - Springer
The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has
recently gained interest, and different DDR inhibitors have been developed. Among them …

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

E Berglund, J Maaskola, N Schultz, S Friedrich… - Nature …, 2018 - nature.com
Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …

Natural small molecules in breast cancer treatment: understandings from a therapeutic viewpoint

MR Islam, F Islam, MH Nafady, M Akter, S Mitra, R Das… - Molecules, 2022 - mdpi.com
Breast cancer (BrCa) is the most common malignancy in women and the second most
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …

Polyphenols in cancer prevention: New insights

G Briguglio, C Costa, M Pollicino… - International …, 2020 - spandidos-publications.com
A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due
to the contribution of natural polyphenols, could reduce the incidence of specific cancers …

Phyllanthin inhibits MOLT‐4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway

H Wang, A Chinnathambi, TA Alahmadi… - … of biochemical and …, 2021 - Wiley Online Library
Among cancers, leukemia is a multistep progression that involves genetic modifications of
normal hematopoietic progenitor cells to cancerous cells. In recent times, leukemia cases …

ROS‐mediated cancer cell killing through dietary phytochemicals

S NavaneethaKrishnan, JL Rosales… - Oxidative medicine and …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations,
activating oncogenes, and raising oxidative stress, which all influence cell proliferation …

Effects and mechanisms of resveratrol for prevention and management of cancers: An updated review

SX Wu, RG Xiong, SY Huang, DD Zhou… - Critical Reviews in …, 2023 - Taylor & Francis
Cancer is a severe public health problem. Resveratrol is a famous natural compound that
has various bioactivities, such as antioxidant, anti-inflammatory, antidiabetic and antiaging …