The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Background Mounting evidence suggests that the choroid plexus (CP) plays an important
role in the pathophysiology of Alzheimer disease (AD), but its imaging profile in cognitive …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased
blood–brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) …

The central nervous system (CNS) encompasses the brain and spinal cord and is
considered the processing center and the most vital part of human body. The central …

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …