Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Phase separation is thought to underlie spatial and temporal organization that is required for
controlling biochemical reactions in cells. Multivalence of interaction motifs, also known as …

Mutations are at the root of many human diseases. Still, we largely do not exactly
understand how they trigger pathogenesis. One, more recent, hypothesis has been that they …

Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range
of neurotoxic aggregates that are associated with Huntington's disease. Here, we show that …

The accumulation of damaged and aggregated proteins is a hallmark of aging and
increased proteotoxic stress. To limit the toxicity of damaged and aggregated proteins and to …

Cells adapt to conditions that compromise protein conformational stability by activating
various stress response pathways, but the mechanisms used in sensing misfolded proteins …

Huntington's disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-
terminal exon of huntingtin (HttEx1), but the cellular mechanisms leading to …

Huntington's disease (HD) is caused by a genetic mutation that results in polyglutamine
expansion in the N-terminal regions of huntingtin. As a result, this polyQ expansion leads to …

The dimensions that unfolded proteins, including intrinsically disordered proteins (IDPs),
adopt in the absence of denaturant remain controversial. We developed an analysis …