[HTML][HTML] The technology, opportunities and challenges of synthetic biological intelligence
Integrating neural cultures developed through synthetic biology methods with digital
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …
computing has enabled the early development of Synthetic Biological Intelligence (SBI) …
[HTML][HTML] Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation
Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
We have generated a controlled and manipulable resource that captures genetic risk for
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease
To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
Growing evidence implicates the importance of glia, particularly astrocytes, in neurological
and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation …
and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation …
Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …
Global landscape and dynamics of Parkin and USP30-dependent ubiquitylomes in iNeurons during mitophagic signaling
The ubiquitin ligase Parkin, protein kinase PINK1, USP30 deubiquitylase, and p97
segregase function together to regulate turnover of damaged mitochondria via mitophagy …
segregase function together to regulate turnover of damaged mitochondria via mitophagy …
Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
INTRODUCTION Chromosomal conformations, topologically associated chromatin domains
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …
(TADs) assembling in nested fashion across hundreds of kilobases, and other “three …