Metastatic colorectal cancer (CRC) with a mismatch repair-deficiency (MMR-
D)/microsatellite instability-high (MSI-H) phenotype carries unique characteristics such as …

Tumor-infiltrating lymphocytes (TILs) are an important histopathologic feature of colorectal
cancer that confer prognostic information. Previous clinical and epidemiologic studies have …

Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …

Purpose: To determine the prevalence and prognostic value of mismatch repair (MMR)
status and its relation to BRAF mutation (BRAF MT) status in metastatic colorectal cancer …

Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

The immune system can identify and destroy nascent tumor cells in a process termed cancer
immunosurveillance, which functions as an important defense against cancer. Recently …

Background & Aims DNA mismatch repair deficiency drives microsatellite instability (MSI).
Cells with MSI accumulate numerous frameshift mutations. Frameshift mutations affecting …

The immune system can recognize and attack cancer cells, especially those with a high load
of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair …

The ability of the immune system to identify and destroy nascent tumors, and to thereby
function as a primary defense against cancer, has been debated for many decades. Recent …

Background: The role of tumour-infiltrating inflammation in the prognosis of patients with
colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta …