Although it was long thought that eukaryotic translation almost always initiates at an AUG
start codon, recent advancements in ribosome footprint mapping have revealed that non …

Abstract mRNA medicine is a new and rapidly developing field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …

Understanding translational control in gene expression relies on precise and
comprehensive determination of translation initiation sites (TIS) across the entire …

Trinucleotide expansions cause disease by both protein-and RNA-mediated mechanisms.
Unexpectedly, we discovered that CAG expansion constructs express homopolymeric …

Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic
diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing …

Ribosome profiling data report on the distribution of translating ribosomes, at steady‐state,
with codon‐level resolution. We present a robust method to extract codon translation rates …

The codon composition of the coding sequence's (ORF) 5′ end first few dozen codons is
known to be distinct to that of the rest of the ORF. Various explanations for the unusual …

Osteopontin (Opn) contributes to diverse biological processes that include immune
responses, vascularization, and bone formation. Until recently, studies describing the …

It is widely suggested that a eukaryotic mRNA typically contains one translation start site and
encodes a single functional protein product. However, according to current points of view on …

Usage of presumed 5′ UTR or downstream in-frame AUG codons, next to non-AUG codons
as translation start codons contributes to the diversity of a proteome as protein isoforms …