Respiratory syncytial virus infection and novel interventions

AC Langedijk, LJ Bont - Nature Reviews Microbiology, 2023 - nature.com
The large global burden of respiratory syncytial virus (RSV) respiratory tract infections in
young children and older adults has gained increased recognition in recent years. Recent …

The road to approved vaccines for respiratory syncytial virus

TJ Ruckwardt - NPJ vaccines, 2023 - nature.com
After decades of work, several interventions to prevent severe respiratory syncytial virus
(RSV) disease in high-risk infant and older adult populations have finally been approved …

Molecular and phenotypic characteristics of RSV infections in infants during two nirsevimab randomized clinical trials

B Ahani, KM Tuffy, AA Aksyuk, D Wilkins… - Nature …, 2023 - nature.com
Nirsevimab is a monoclonal antibody that binds to the respiratory syncytial virus (RSV)
fusion protein. During the Phase 2b (NCT02878330) and MELODY (NCT03979313) clinical …

Clinical, genomic, and immunological characterization of RSV surge in Sydney, Australia, 2022

GJ Walker, CSP Foster, A Sevendal… - …, 2024 - publications.aap.org
OBJECTIVES The 2022 seasonal respiratory syncytial virus (RSV) epidemic in Sydney,
Australia saw an unprecedented number of RSV detections. We aimed to characterize …

[HTML][HTML] Nirsevimab for the prevention of respiratory syncytial virus disease in children. Statement of the Spanish Society of Paediatric Infectious Disease (SEIP)

L Francisco, M Cruz-Canete, C Pérez… - Anales de Pediatría …, 2023 - Elsevier
Introduction Nirsevimab, a monoclonal antibody for the prevention of disease caused by
respiratory syncytial virus (RSV), has recently been approved for use in Europe and Spain …

The respiratory syncytial virus vaccine and monoclonal antibody landscape: the road to global access

J Terstappen, SF Hak, A Bhan, D Bogaert… - The Lancet Infectious …, 2024 - thelancet.com
Respiratory syncytial virus (RSV) is the second most common pathogen causing infant
mortality. Additionally, RSV is a major cause of morbidity and mortality in older adults (age≥ …

[HTML][HTML] The path towards effective respiratory syncytial virus immunization policies: recommended actions

F Martinón-Torres, JA Navarro-Alonso… - Archivos de …, 2023 - Elsevier
The respiratory syncytial virus (RSV) causes a substantial burden worldwide. After over six
decades of research, there is finally a licensed immunization option that can protect the …

Current state and challenges in respiratory syncytial virus drug discovery and development

G Zou, S Cao, Z Gao, J Yie, JZ Wu - Antiviral Research, 2023 - Elsevier
Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract
infections (LRTI) in young children and elderly people worldwide. Recent significant …

Systematic Review of the Efficacy and Safety of RSV‐Specific Monoclonal Antibodies and Antivirals in Development

ATK Sevendal, S Hurley, AW Bartlett… - Reviews in Medical …, 2024 - Wiley Online Library
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection amongst
all ages, causing a significant global health burden. Preventative and therapeutic options for …

The beginning of a new era in RSV control

HC Meissner - Pediatrics, 2023 - publications.aap.org
Since the initial isolation in 1956 of what is now identified as respiratory syncytial virus
(RSV), seasonal outbreaks of illness attributable to this enigmatic respiratory virus have …