Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …

Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family
member, acts as an oncogenic driver in hematological malignancies and promotes tumor …

Animal development depends on not only the linear genome sequence that embeds millions
of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that …

Chromatin looping is key to gene regulation, yet no broadly applicable methods to
selectively modify chromatin loops have been described. We have engineered a method for …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

It can be convenient to think of the genome as simply a string of nucleotides, the linear order
of which encodes an organism's genetic blueprint. However, the genome does not exist as a …

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it
provides a unique assay to study the interplay between transcription factors and chromatin …

Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …

Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be
recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to …