Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …

Objective Cellular senescence, an irreversible proliferative cell arrest, is caused by
excessive intracellular or extracellular stress/damage. Increased senescent cells have been …

Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Obesity with dysfunctional adipose cells is the major cause of the current epidemic of type 2
diabetes (T2D). We examined senescence in human adipose tissue cells from age-and BMI …

For the past several decades, the prevalence of obesity and type 2 diabetes (T2D) has
continued to rise on a global level. The risk contributing to this pandemic implicates both …

MicroRNAs, or miRNAs, may involve in coagulation and inflammation pathways caused by
severe Coronavirus disease (COVID-19). Accordingly, this attempt was made to explore the …