Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Cells have evolved multiple mechanisms to apprehend and adapt finely to their
environment. Here we report a new cellular ability, which we term “curvotaxis” that enables …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

Injuries to the peripheral nervous system (PNS) cause neuropathies that lead to weakness
and paralysis, poor or absent sensation, unpleasant and painful neuropathies, and impaired …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

An early step of metastasis requires a complex and coordinated migration of invasive tumor
cells into the surrounding tumor microenvironment (TME), which contains extracellular …

The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …