GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway. Gli2
mutant mice have hypoplastic anterior and absent posterior pituitary glands. We reviewed …

Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease.
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …

Purpose: Patients with aggressive thyroid cancer are frequently failed by the central therapy
of ablative radioiodide (RAI) uptake, due to reduced plasma membrane (PM) localization of …

In eukaryotic cells, clathrin‐mediated endocytosis (CME) is a central pathway for the
internalization of proteins from the cell surface, thereby contributing to the maintenance of …

While in most patients with non-medullary thyroid cancer (TC), disease remission is
achieved by thyroidectomy and ablation of tumor remnants by radioactive iodide (RAI), a …

The groundbreaking research work about SIGLEC15 has raised it as a potential promising
target in cancer immunotherapy. Unfortunately, the role of SIGLEC15 in thyroid carcinoma …

Pathogenic gene variants in humans that affect the sonic hedgehog (SHH) pathway lead to
severe brain malformations with variable penetrance due to unknown modifier genes. To …

Purpose The conventional interventions of anaplastic thyroid carcinoma (ATC) patients are
mainly through surgery, chemotherapy, and radiotherapy; however, it is hardly to improve …

Members of the pituitary tumor transforming gene (PTTG) family, including PTTG1, PTTG2
and PTTG3P, exhibit pivotal roles in the onset and progression of certain types of human …

Extracellular vesicles (EVs) are promising therapeutic delivery vehicles, although their
potential is limited by a lack of efficient engineering strategies to enhance loading and …