Systematic review of polygenic risk scores for type 1 and type 2 diabetes

F Padilla-Martínez, F Collin, M Kwasniewski… - International journal of …, 2020 - mdpi.com
Recent studies have led to considerable advances in the identification of genetic variants
associated with type 1 and type 2 diabetes. An approach for converting genetic data into a …

Heritability and genetics of type 2 diabetes mellitus in Sub‐Saharan Africa: a systematic review and meta‐analysis

EA Asamoah, C Obirikorang… - Journal of diabetes …, 2020 - Wiley Online Library
Objectives. Sub‐Saharan Africa (SSA) is observing an accelerating prevalence rate of type 2
diabetes mellitus (T2DM) influenced by gene‐environment interaction of modifiable and …

Genetic basis of obesity and type 2 diabetes in Africans: impact on precision medicine

AP Doumatey, K Ekoru, A Adeyemo… - Current Diabetes Reports, 2019 - Springer
Abstract Purpose of Review Recent advances in genomics provide opportunities for novel
understanding of the biology of human traits with the goal of improving human health. Here …

Predictive utility of a genetic risk score of common variants associated with type 2 diabetes in a black South African population

T Chikowore, T van Zyl, EJM Feskens… - Diabetes research and …, 2016 - Elsevier
Aims To determine the predictive utility of polygenic risk scores of common variants
associated with type 2 diabetes derived from the European and Asian ethnicities among a …

[HTML][HTML] Viscoelasticity as a measurement of clot structure in poorly controlled type 2 diabetes patients: towards a precision and personalized medicine approach

E Pretorius, J Bester - Oncotarget, 2016 - ncbi.nlm.nih.gov
Objectives Type 2 diabetes patients (T2D) have a considerably higher cardiovascularrisk,
which is closely associated with systemic inflammation, and an accompanying pathologic …

Novel association between the nonsynonymous A803G polymorphism of the N‐acetyltransferase 2 gene and impaired glucose homeostasis in obese children and …

P Marzuillo, A Di Sessa, GR Umano… - Pediatric …, 2017 - Wiley Online Library
Background The N‐acetyltransferase 2 (NAT2) A803G polymorphism has been associated
with decreased insulin sensitivity in a large adult population with the A allele associated with …

C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population

F Han, L Qian, Y Zhang, P Liu, R Li, M Chen - Functional & Integrative …, 2022 - Springer
Background The mRNA levels of C2CD4A and C2CD4B were dysregulation in lung cancer
(LC). We aimed to evaluate the role of C2CD4A/B variants in LC susceptibility. Methods …

David Bowie and the Art of Slow Innovation: A Fast-Second Winner Strategy for Biotechnology and Precision Medicine Global Development

V Özdemir, GP Patrinos - OMICS: A Journal of Integrative Biology, 2017 - liebertpub.com
Original ideas and innovation cannot always be ordered like a courier service and delivered
fresh to our desk at 9 am. Yet, most creativity-based organizations, careers, and professions …

Liver proteome in diabetes type 1 rat model: Insulin-dependent and-independent changes

CP Braga, CHT Boone, RA Grove… - Omics: a journal of …, 2016 - liebertpub.com
Abstract Diabetes mellitus type 1 (DM1) is a major public health problem that continues to
burden the healthcare systems worldwide, costing exponentially more as the epidemic …

Nutritional research at North-West University 1998-2018: impact, scope and reach through evidence mapping

ML Grundlingh - 2020 - repository.nwu.ac.za
Background and objectives: The growing evidence base of nutrition research provides
ample evidence that could potentially inform public health nutrition related policies …