[HTML][HTML] Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome

JS Knight, Y Kanthi - Seminars in immunopathology, 2022 - Springer
Antiphospholipid syndrome (APS) is an autoimmune thrombophilia propelled by circulating
antiphospholipid antibodies that herald vascular thrombosis and obstetrical complications …

Antiphospholipid syndrome

K Schreiber, S Sciascia, PG De Groot… - Nature reviews Disease …, 2018 - nature.com
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence
of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and …

Lipid presentation by the protein C receptor links coagulation with autoimmunity

N Müller-Calleja, A Hollerbach, J Royce, S Ritter… - Science, 2021 - science.org
INTRODUCTION Antiphospholipid antibodies (aPLs) transiently appear in infectious
diseases but can persist in primary antiphospholipid syndrome (APS) or in association with …

The pathogenesis of the antiphospholipid syndrome

B Giannakopoulos, SA Krilis - New England Journal of Medicine, 2013 - Mass Medical Soc
The antiphospholipid syndrome is a prothrombotic disorder associated with autoantibodies.
It is associated with obstetrical complications (mainly spontaneous abortion) as well as …

Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

[HTML][HTML] Pathogenesis, diagnosis and management of obstetric antiphospholipid syndrome: a comprehensive review

J Alijotas-Reig, E Esteve-Valverde… - Journal of clinical …, 2022 - mdpi.com
Antiphospholipid syndrome is an autoimmune disorder characterized by vascular
thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibody …

Antiphospholipid syndrome: role of vascular endothelial cells and implications for risk stratification and targeted therapeutics

MT Corban, A Duarte-Garcia, RD McBane… - Journal of the American …, 2017 - jacc.org
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous
thromboembolism, arterial thrombosis, and obstetric morbidities in the setting of persistently …

[HTML][HTML] β2‐Glycoprotein I: evolution, structure and function

PG De Groot, JCM Meijers - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …

Interplay of low-density lipoprotein receptors, LRPs, and lipoproteins in pulmonary hypertension

L Calvier, J Herz, G Hansmann - Basic to Translational Science, 2022 - jacc.org
The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

The significance of autoantibodies against β2-glycoprotein I

PG de Groot, RT Urbanus - Blood, The Journal of the American …, 2012 - ashpublications.org
The antiphospholipid syndrome (APS) is defined by the persistent presence of
antiphospholipid antibodies in patients with a history of thrombosis and/or pregnancy …