Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

To the Editor—Ribosome profiling (Ribo-seq) has extended our understanding of the
translational 'vocabulary'of the human genome, uncovering thousands of open reading …

The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins
encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA) …

Single‐cell technologies are revolutionizing biology but are today mainly limited to imaging
and deep sequencing. However, proteins are the main drivers of cellular function and in …

All species continuously evolve short open reading frames (sORFs) that can be templated
for protein synthesis and may provide raw materials for evolutionary adaptation. We …

Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

The identification of actionable tumor antigens is indispensable for the development of
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …

While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last
decade, the focus regarding their mechanisms of action has been primarily on the RNA …

The remarkable success of immune checkpoint inhibitors demonstrates the potential of
tumour-specific CD8+ T cells to prevent and treat cancer. Although the number of lives …