Protein ubiquitination, one of the most significant post-translational modifications, plays an
important role in controlling the proteins activity in diverse cellular processes. The reversible …

Simple Summary Cancers have many genetic mutations such as nucleotide changes,
deletions, amplifications, and chromosome gains or losses. Some of these genetic …

Background Hyper-activation of TGF-β signaling is critically involved in progression of
hepatocellular carcinoma (HCC). However, the events that contribute to the dysregulation of …

ABSTRACT DNA methylation on CpGs regulates transcription in mammals, both by
decreasing the binding of methylation-repelled factors and by increasing the binding of …

Abstract Picrorhiza kurroa Royle ex Benth.(P. kurroa/PK/Kutki), a Himalayan herb belonging
to the family Scrophulariaceae, is widely known for its hepatoprotective activity. Traditionally …

DNA methylation plays an essential role in the control of gene expression during early
stages of development as well as in disease. Although many transcription factors are …

Affinity purification followed by mass spectrometry has become the technique of choice to
identify binding partners in biochemical complexes isolated from a physiologic cellular …

Introduction Aberrant reactive oxygen species (ROS) production is one of the hallmarks of
cancer. During their growth and dissemination, cancer cells control redox signaling to …

Bladder cancer is the most common malignancy of the urinary tract, and~ 50% of patients
with bladder cancer experience recurrence and metastasis. The results of mass …

K-RAS mutation and molecular alterations of its surrogates function essentially in lung
tumorigenesis and malignant progression. However, it remains elusive how tumor …