Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated
successfully with surgery alone and survival rates are high, but after metastasis survival …

Introduction: While selected/multiple-reaction monitoring (SRM or MRM) is considered the
gold standard for quantitative protein measurement, emerging data-independent acquisition …

Large panels of comprehensively characterized human cancer models, including the
Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to …

Oxygen sensing is central to metazoan biology and has implications for human disease.
Mammalian cells express multiple oxygen-dependent enzymes called 2-oxoglutarate (OG) …

Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes
due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+ CD24 …

Members of the KDM5 histone H3 lysine 4 demethylase family are associated with
therapeutic resistance, including endocrine resistance in breast cancer, but the underlying …

BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative
breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs …

Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21)
and characterized by a wide range of neurodevelopmental and physical disabilities …

Systemic metabolic alterations associated with increased consumption of saturated fat and
obesity are linked with increased risk of prostate cancer progression and mortality, but the …

The epigenome is a key determinant of transcriptional output. Perturbations within the
epigenome are thought to be a key feature of many, perhaps all cancers, and it is now clear …