Thalassemias are a group of inherited blood disorders that affects 5–7% of the world
population. Comprehensive screening strategies are essential for the management and …

There is inconsistency in the exact definition of diagnostic levels of HbA 2 for β thalassemia
trait. While many laboratories consider HbA 2≥ 4.0% diagnostic, still others consider HbA …

Increased HbA2 levels are the characteristic feature of β-thalassemia carriers. A subset of
carriers however do not show HbA2 levels in the typical carrier range (≥ 4.0%) but show …

Alpha thalassemia (α-thalassemia) is an autosomal recessive disorder due to the reduction
or absence of α globin chain production. Laboratory diagnosis of α-thalassemia requires …

Thalassemia is identified as a prevalent disease in Malaysia, known to be one of the
developing countries. Fourteen patients with confirmed cases of thalassemia were recruited …

Although considered a mild clinical condition, many laboratory issues of the carrier state of β-
thalassemia remain unresolved. Accurate laboratory screening of β-thalassemia traits is …

Hemoglobinopathies are common genetic disorders of the hemoglobin (Hb) molecule.
Globally, 7.0% of the population are carriers of thalassemia with 300,000–400,000 affected …

Abstract Elevated Hb A2 level (≥ 4.0%) is considered to be reliable parameter to identify β-
thalassemia (β-thal) carriers. However, some β-thal carriers have been misdiagnosed as …

Background It is difficult to classify a small fraction of α-and β-thalassemia (α-and β-thal)
carriers based on their Hb A2 levels. Here, we report the results of a molecular investigation …

BACKGROUND: Himachal Pradesh is a hill state in North India in the Western Himalayas. β-
thalassemia is a genetic disorder of hemoglobin inherited in an autosomal recessive …