Exosomes are nanovesicles secreted by most cellular types that carry important biochemical
compounds throughout the body with different purposes, playing a preponderant role in …

Exosomes are extracellular vesicles of endosomal origin that are released by practically all
cell types across metazoans. Exosomes are active vehicles of intercellular communication …

Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However,
experimental studies in mice also suggest that chemotherapy has pro-metastatic effects …

Filamentous (oomycete and fungal) plant pathogens deliver cytoplasmic effector proteins
into host cells to facilitate disease. How RXLR effectors from the potato late blight pathogen …

Oncogenic Ras mutants, frequently detected in human cancers, are high-priority anticancer
drug targets. However, direct inhibition of oncogenic Ras mutants with small molecules has …

Organelles not only constitute the basic structure of the cell but also are important in
maintaining the normal physiological activities of the cell. With the development of …

Exosomes, a subgroup of extracellular vesicles secreted by multiple cells, have great
potential as cancer biomarkers in clinical applications. However, enrichment and detection …

Resistance to BRAF and MEK inhibitors (BRAFi+ MEKi) in BRAF-mutant tumors occurs
through heterogeneous mechanisms, including ERK reactivation and autophagy. Little is …

The liver plays a central role in regulating glucose and lipid metabolism. Aberrant insulin
action in the liver is a major driver of selective insulin resistance, in which insulin fails to …

Niemann-Pick type C disease (NPC) is a rare inherited neurodegenerative disorder
characterized by an accumulation of intracellular cholesterol within late endosomes and …