The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

Potassium homeostasis has a very high priority because of its importance for membrane
potential. Although extracellular K+ is only 2% of total body K+, our physiology was …

We describe the development and characterization of a mouse and human epithelial cell
monolayer platform of the small and large intestines, with a broad range of potential …

Current therapies to treat gastroesophageal reflux disease (GERD), peptic ulcer disease
(PUD), and other acid-related diseases either prevent stimulation of the parietal cell (H2 …

The H+-K+-ATPases are ion pumps that use the energy of ATP hydrolysis to transport
protons (H+) in exchange for potassium ions (K+). These enzymes consist of a catalytic α …

Previous studies using isolated tissues suggest that the colonic H, K-ATPase (cHKA),
expressed in the colon and kidney, plays an important role in K+ conservation. To test the …

Homeostatic control of plasma K+ is a necessary physiological function. The daily dietary K+
intake of~ 100 mmol is excreted predominantly by the distal tubules of the kidney. About …

The colon has large capacities for K+ absorption and K+ secretion, but its role in maintaining
K+ homeostasis is often overlooked. For many years, passive diffusion and/or solvent drag …

Molecular cloning experiments have identified the existence of two H+-K+-ATPases (HKAs),
colonic and gastric. Recent functional and molecular studies indicate the presence of both …

The uriniferous tubule is divided into the proximal tubule, the intermediate (thin) tubule, the
distal tubule and the collecting duct. The present chapter is based on the chapters by …