[HTML][HTML] Antimicrobial peptides: A new hope in biomedical and pharmaceutical fields

A Moretta, C Scieuzo, AM Petrone, R Salvia… - Frontiers in cellular …, 2021 - frontiersin.org
Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use
contributes to the development and spread of drug-resistant microorganisms. Antibiotic …

Immune modulation by bacterial outer membrane vesicles

M Kaparakis-Liaskos, RL Ferrero - Nature Reviews Immunology, 2015 - nature.com
Gram-negative bacteria shed extracellular outer membrane vesicles (OMVs) during their
normal growth both in vitro and in vivo. OMVs are spherical, bilayered membrane …

Outer membrane vesicles: biogenesis, functions, and issues

R Juodeikis, SR Carding - Microbiology and Molecular Biology …, 2022 - Am Soc Microbiol
This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial
extracellular vesicles (BEVs) produced by Gram-negative organisms focusing on the …

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

NR Salama, ML Hartung, A Müller - Nature Reviews Microbiology, 2013 - nature.com
The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes
approximately 50% of the human population, but only causes overt gastric disease in a …

NOD1 and NOD2 in inflammation, immunity and disease

T Mukherjee, ES Hovingh, EG Foerster… - Archives of biochemistry …, 2019 - Elsevier
NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to
the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and …

Pathogenesis of Helicobacter pylori infection

V Camilo, T Sugiyama, E Touati - Helicobacter, 2017 - Wiley Online Library
Helicobacter pylori is responsible for the most commonly found infection in the world's
population. It is the major risk factor for gastric cancer development. Numerous studies …

NOD1 and NOD2 in inflammatory and infectious diseases

BC Trindade, GY Chen - Immunological reviews, 2020 - Wiley Online Library
It has been long recognized that NOD1 and NOD2 are critical players in the host immune
response, primarily by their sensing bacterial peptidoglycan‐conserved motifs. Significant …

NOD1 and NOD2 signaling in infection and inflammation

LO Moreira, DS Zamboni - Frontiers in immunology, 2012 - frontiersin.org
Sensing intracellular pathogens is a process mediated by innate immune cells that is crucial
for the induction of inflammatory processes and effective adaptive immune responses …

Mechanisms and regulation of defensins in host defense

J Fu, X Zong, M Jin, J Min, F Wang… - Signal Transduction and …, 2023 - nature.com
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

[PDF][PDF] The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling

AT Irving, H Mimuro, TA Kufer, C Lo, R Wheeler… - Cell host & …, 2014 - cell.com
The intracellular innate immune receptor NOD1 detects Gram-negative bacterial
peptidoglycan (PG) to induce autophagy and inflammatory responses in host cells. To date …