[HTML][HTML] Potential clinical and economic impact of switching branded medications to generics
RJ Straka, DJ Keohane, LZ Liu - American journal of therapeutics, 2017 - journals.lww.com
Switching branded to generic medications has become a common cost-containment
measure. Although this is an important objective for health care systems worldwide, the …
measure. Although this is an important objective for health care systems worldwide, the …
[HTML][HTML] Potential problems and recommendations regarding substitution of generic antiepileptic drugs: a systematic review of literature
Despite the availability of generic antiepileptic drugs (AEDs), still patients and neurologists
hesitate to make a switch due to assorted reasons. The objectives of this review were to …
hesitate to make a switch due to assorted reasons. The objectives of this review were to …
Therapeutic basis of generic substitution of antiseizure medications
S Elmer, DS Reddy - Journal of Pharmacology and Experimental …, 2022 - ASPET
More than thirty antiseizure medications (ASMs) are available for treating epilepsy. ASMs
differ in their potency and efficacy in controlling seizures by acting on diverse targets in the …
differ in their potency and efficacy in controlling seizures by acting on diverse targets in the …
Biowaiver monographs for immediate release solid oral dosage forms: levetiracetam
M Petruševska, S Berglez, I Krisch, I Legen… - Journal of …, 2015 - Elsevier
Literature and experimental data relevant for the decision to allow a waiver of in vivo
bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage …
bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage …
[HTML][HTML] The impact of generic substitution on health and economic outcomes: a systematic review
H Gothe, I Schall, K Saverno, M Mitrovic… - … health economics and …, 2015 - Springer
Background Generic drugs are considered therapeutically equivalent to their original
counterparts and lower in acquisition costs. However, the overall impact of generic …
counterparts and lower in acquisition costs. However, the overall impact of generic …
[HTML][HTML] Evaluating therapeutic equivalence of generic and original levetiracetam in patients with epilepsy: a retrospective study
J Tharavichitkun, T Yadee, P Angkaow… - Neurology …, 2022 - mdpi.com
The brand interchangeability of antiepileptic drugs (AEDs) is a topic of debate, especially
regarding their therapeutic equivalence. This study evaluates the efficacy and tolerability of …
regarding their therapeutic equivalence. This study evaluates the efficacy and tolerability of …
Safety of overnight switch from brand-name to generic levetiracetam
MS Vari, F Pinto, E Mencaroni, G Giudizioso… - Clinical drug …, 2016 - Springer
Abstract Background and Objective Concerns that antiepileptic brand-to-generic
interchange results in disruption of seizure control are widespread. The objective of this …
interchange results in disruption of seizure control are widespread. The objective of this …
Impact of generic substitution on levetiracetam serum concentration—A prospective study in an outpatient setting
Background Switching patients from a branded antiepileptic drug (AED) to a generic is often
challenging. Several studies have shown that considerable proportions of patients report …
challenging. Several studies have shown that considerable proportions of patients report …
Population pharmacokinetics and dosing recommendations of levetiracetam in adult and elderly patients with epilepsy
MP Hernández-Mitre, SE Medellín-Garibay… - Journal of …, 2020 - Elsevier
The objective was to develop and externally validate a population pharmacokinetic model of
levetiracetam in adult and elderly patients with epilepsy, and to perform dosing simulations …
levetiracetam in adult and elderly patients with epilepsy, and to perform dosing simulations …
Understanding authorized generics—A review of the published clinical data
J Alderfer, RA Hansen… - Journal of clinical …, 2021 - Wiley Online Library
What is known and objectives Despite the large body of evidence demonstrating equivalent
efficacy and safety for branded drugs and their generic counterparts, some patients and …
efficacy and safety for branded drugs and their generic counterparts, some patients and …