Switching branded to generic medications has become a common cost-containment
measure. Although this is an important objective for health care systems worldwide, the …

Despite the availability of generic antiepileptic drugs (AEDs), still patients and neurologists
hesitate to make a switch due to assorted reasons. The objectives of this review were to …

More than thirty antiseizure medications (ASMs) are available for treating epilepsy. ASMs
differ in their potency and efficacy in controlling seizures by acting on diverse targets in the …

Literature and experimental data relevant for the decision to allow a waiver of in vivo
bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage …

Background Generic drugs are considered therapeutically equivalent to their original
counterparts and lower in acquisition costs. However, the overall impact of generic …

The brand interchangeability of antiepileptic drugs (AEDs) is a topic of debate, especially
regarding their therapeutic equivalence. This study evaluates the efficacy and tolerability of …

Abstract Background and Objective Concerns that antiepileptic brand-to-generic
interchange results in disruption of seizure control are widespread. The objective of this …

Background Switching patients from a branded antiepileptic drug (AED) to a generic is often
challenging. Several studies have shown that considerable proportions of patients report …

The objective was to develop and externally validate a population pharmacokinetic model of
levetiracetam in adult and elderly patients with epilepsy, and to perform dosing simulations …

What is known and objectives Despite the large body of evidence demonstrating equivalent
efficacy and safety for branded drugs and their generic counterparts, some patients and …