The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

It is well established that multifactorial drug resistance hinders successful cancer treatment.
Tumor cell interactions with the tumor microenvironment (TME) are crucial in epithelial …

Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

Cancer is a systemic disease encompassing multiple components of both tumor cells
themselves and host stromal cells. It is now clear that stromal cells in the tumor …

Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of
soluble factors, extracellular matrix components and extracellular vesicles. While in …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Cancer associated fibroblasts (CAFs) are a subpopulation of cells that reside within the
tumor microenvironment and promotes the transformation process by encouraging tumor …

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of
poor prognosis in human breast cancer patients, and is associated with early tumor …

Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells
induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the …

Colorectal cancer (CRC) progression and eventually metastasis is directed in many aspects
by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer …