Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome

CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …

Concise review: multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine

RM Samsonraj, M Raghunath… - Stem cells …, 2017 - academic.oup.com
Mesenchymal stem cells (MSC) hold great potential for regenerative medicine because of
their ability for self-renewal and differentiation into tissue-specific cells such as osteoblasts …

Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity

Y Zhou, Y Yamamoto, Z Xiao, T Ochiya - Journal of clinical medicine, 2019 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …

Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?

A Oryan, A Kamali, A Moshiri… - Cells Tissues …, 2017 - karger.com
Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Acute-on-chronic liver failure: terminology, mechanisms and management

SK Sarin, A Choudhury - Nature Reviews Gastroenterology & …, 2016 - nature.com
Acute-on-chronic liver failure (ACLF) is a distinct clinical entity and differs from acute liver
failure and decompensated cirrhosis in timing, presence of acute precipitant, course of …

hucMSC exosome-derived GPX1 is required for the recovery of hepatic oxidant injury

Y Yan, W Jiang, Y Tan, S Zou, H Zhang, F Mao… - Molecular Therapy, 2017 - cell.com
Exosomes are small biological membrane vesicles secreted by various cells, including
mesenchymal stem cells (MSCs). We previously reported that MSC-derived exosomes (MSC …

Pathogenesis, early diagnosis, and therapeutic management of alcoholic liver disease

LZ Kong, N Chandimali, YH Han, DH Lee… - International journal of …, 2019 - mdpi.com
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to
alcohol overconsumption. It consists of fatty liver/steatosis, alcoholic hepatitis …

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

L Chen, F Lu, D Chen, J Wu, L Xu, M Zheng, H Li… - Molecular …, 2018 - Elsevier
Autoimmune hepatitis is a chronic inflammatory disease in the liver with potential to the
development of liver fibrosis. Recent evidences suggest that bone marrow derived …

Cell and tissue engineering for liver disease

SN Bhatia, GH Underhill, KS Zaret, IJ Fox - Science translational …, 2014 - science.org
Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …