Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric
cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial …

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

Diffuse gastric cancers typically present as late‐stage tumours and, as a result, the 5 year
survival rate is poor. Some gastric cancers are hereditary and these tend to be of the diffuse …

Abstract Approximately 5–10% of breast cancer cases might be inheritable, up to 30% of
which are due to BRCA1/2 mutations. During the past few years and thanks to technology …

Gastric cancer is the third leading cause of cancer-related deaths and ranks as the fifth most
common cancer worldwide. Incidence and mortality differ depending on the geographical …

Infiltrating lobular breast cancer (ILBC) is the most common special breast cancer subtype.
This review provides a comprehensive description of ILBC characteristics, including …

CDH1 encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is
involved in major cellular processes such as embryogenesis and maintenance of tissue …

Hereditary diffuse gastric cancer (HDGC) is a dominantly inherited cancer syndrome
characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer …

Background Gastric cancer is the second-leading cause of global cancer deaths, with
metastatic disease representing the primary cause of mortality. To identify candidate drivers …