Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches

P Düsing, A Zietzer, PR Goody, MR Hosen… - Journal of molecular …, 2021 - Springer
Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …

[HTML][HTML] The systemic nature of CKD

C Zoccali, R Vanholder, ZA Massy, A Ortiz… - Nature Reviews …, 2017 - nature.com
The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …

Inflammation and premature ageing in chronic kidney disease

T Ebert, SC Pawelzik, A Witasp, S Arefin, S Hobson… - Toxins, 2020 - mdpi.com
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia

J Voelkl, F Lang, KU Eckardt, K Amann… - Cellular and Molecular …, 2019 - Springer
Medial vascular calcification has emerged as a putative key factor contributing to the
excessive cardiovascular mortality of patients with chronic kidney disease (CKD) …

Alkaline phosphatase: a novel treatment target for cardiovascular disease in CKD

M Haarhaus, V Brandenburg… - Nature Reviews …, 2017 - nature.com
Cardiovascular disease is the main cause of early death in the settings of chronic kidney
disease (CKD), type 2 diabetes mellitus (T2DM), and ageing. Cardiovascular events can be …

Review of potential health risks associated with nanoscopic calcium phosphate

M Epple - Acta biomaterialia, 2018 - Elsevier
Calcium phosphate is applied in many products in biomedicine, but also in toothpastes and
cosmetics. In some cases, it is present in nanoparticulate form, either on purpose or after …

A randomized trial of magnesium oxide and oral carbon adsorbent for coronary artery calcification in predialysis CKD

Y Sakaguchi, T Hamano, Y Obi, C Monden… - Journal of the …, 2019 - journals.lww.com
Background Developing strategies for managing coronary artery calcification (CAC) in
patients with CKD is an important clinical challenge. Experimental studies have …

Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-Rich Protein)

CSB Viegas, L Santos, AL Macedo… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Inhibition of mineral crystal formation is a crucial step in ectopic calcification.
Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) …

The importance of being amorphous: calcium and magnesium phosphates in the human body

R Gelli, F Ridi, P Baglioni - Advances in colloid and interface science, 2019 - Elsevier
This article focuses on the relevance of amorphous calcium (and magnesium) phosphates in
living organisms. Although crystalline calcium phosphate (CaP)-based materials are known …

The effect of increasing dialysate magnesium on serum calcification propensity in subjects with end stage kidney disease: a randomized, controlled clinical trial

I Bressendorff, D Hansen, M Schou… - Clinical Journal of the …, 2018 - journals.lww.com
Results Fifty-nine subjects were enrolled in the trial, and of these, 57 completed the
intervention and were analyzed for the primary outcome. In the standard dialysate …