Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

SARS-CoV-2 and the spike protein in endotheliopathy

L Perico, A Benigni, G Remuzzi - Trends in Microbiology, 2024 - cell.com
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …

The eukaryotic linear motif resource: 2022 release

M Kumar, S Michael, J Alvarado-Valverde… - Nucleic acids …, 2022 - academic.oup.com
Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource
remains an invaluable source of information for the study of motif-mediated protein-protein …

SARS-CoV-2 down-regulates ACE2 through lysosomal degradation

Y Lu, Q Zhu, DM Fox, C Gao, SA Stanley… - Molecular Biology of …, 2022 - Am Soc Cell Biol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S)
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …

Integrin activation is an essential component of SARS-CoV-2 infection

P Simons, DA Rinaldi, V Bondu, AM Kell, S Bradfute… - Scientific Reports, 2021 - nature.com
SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting
enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be …

Autophagy in health and disease: From molecular mechanisms to therapeutic target

G Lu, Y Wang, Y Shi, Z Zhang, C Huang, W He… - MedComm, 2022 - Wiley Online Library
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19)

M Andrew, G Jayaraman - Carbohydrate Research, 2021 - Elsevier
The viral infection caused by SARS-CoV-2 has increased the mortality rate and engaged
several adverse effects on the affected individuals. Currently available antiviral drugs have …

Possible use of phytochemicals for recovery from COVID-19-induced anosmia and ageusia

S Koyama, K Kondo, R Ueha, H Kashiwadani… - International Journal of …, 2021 - mdpi.com
The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …

An update on angiotensin-converting enzyme 2 structure/functions, polymorphism, and duplicitous nature in the pathophysiology of coronavirus disease 2019 …

CA Devaux, L Camoin-Jau - Frontiers in microbiology, 2022 - frontiersin.org
It has been known for many years that the angiotensin-converting enzyme 2 (ACE2) is a cell
surface enzyme involved in the regulation of blood pressure. More recently, it was proven …

SARS-CoV-2 cellular entry is independent of the ACE2 cytoplasmic domain signaling

T Karthika, J Joseph, VRA Das, N Nair, P Charulekha… - Cells, 2021 - mdpi.com
Recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and-2
initiate virus infection by binding of their spike glycoprotein with the cell-surface receptor …