The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

In this perspective, we provide an overview of a recently established National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

Dysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a
comprehensive understanding of the underlying mechanisms, including gene dysregulation …

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones
insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and …

Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

One hundred years have passed since the discovery of insulin—an achievement that
transformed diabetes from a fatal illness into a manageable chronic condition. The decades …