Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer

BS Katzenellenbogen, VS Guillen… - Breast Cancer …, 2023 - Springer
Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly
upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and …

FOX (M1) news—it is cancer

M Halasi, AL Gartel - Molecular cancer therapeutics, 2013 - AACR
FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined
role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in …

Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

AP Sawaya, RC Stone, SR Brooks, I Pastar… - Nature …, 2020 - nature.com
Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb
amputations and a shortened lifespan. However, molecular mechanisms contributing to the …

Sex-specific features of microglia from adult mice

A Villa, P Gelosa, L Castiglioni, M Cimino, N Rizzi… - Cell reports, 2018 - cell.com
Sex has a role in the incidence and outcome of neurological illnesses, also influencing the
response to treatments. Neuroinflammation is involved in the onset and progression of …

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19

H Tang, Y Gao, Z Li, Y Miao, Z Huang… - Clinical and …, 2020 - Wiley Online Library
Background COVID‐19 is currently a global pandemic, but the response of human immune
system to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection …

Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling

G Wang, B Wen, Z Deng, Y Zhang… - Nature …, 2022 - nature.com
Pulmonary endothelial progenitor cells (EPCs) are critical for neonatal lung angiogenesis
and represent a subset of general capillary cells (gCAPs). Molecular mechanisms through …

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes

MR Staudt, J Salit, RJ Kaner, C Hollmann… - Respiratory research, 2018 - Springer
Background Little is known about health risks associated with electronic cigarette (EC) use
although EC are rising in popularity and have been advocated as a means to quit smoking …

FOXM1: a multifunctional oncoprotein and emerging therapeutic target in ovarian cancer

C Liu, CJ Barger, AR Karpf - Cancers, 2021 - mdpi.com
Simple Summary Ovarian cancer is a lethal disease in women with a 10-year survival rate
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …

Ultra-high dose-rate proton FLASH improves tumor control

S Shukla, T Saha, N Rama, A Acharya, T Le… - Radiotherapy and …, 2023 - Elsevier
Background and purpose Proton radiotherapy (PRT) offers potential benefits over other
radiation modalities, including photon and electron radiotherapy. Increasing the rate at …

The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological …

I Wierstra - Advances in cancer research, 2013 - Elsevier
Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …