The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally
identified as a nuclear factor that binds and activates the promoters of type I interferon …

The composition of the lung microbiome is increasingly well characterised, with changes in
microbial diversity or abundance observed in association with several chronic respiratory …

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

The number of descriptions of emerging viruses has grown at an unprecedented rate since
the beginning of the 21 st century. Severe acute respiratory syndrome coronavirus 2 (SARS …

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

Respiratory syncytial virus (RSV) is one of the most important viral pathogens causing
respiratory tract infection in infants, the elderly and people with poor immune function, which …

Current data indicate that the “bronchiolitis” diagnosis comprises more than one condition.
Clinically, pathophysiologically, and even genetically three main clusters of patients can be …

Viral defense at mucosal sites depends on interferons (IFN) and IFN stimulated genes
(ISGs), either of which may be constitutively expressed to maintain an “antiviral state”(AVS) …

As the capacity for generating large-scale molecular profiling data continues to grow, the
ability to extract meaningful biological knowledge from it remains a limitation. Here, we …

A new series of pyrimidine-5-carbonitrile derivatives 8a-p carrying the 1, 3-thiazole moiety
has been designed and synthesized as novel anti-inflammatory EGFR inhibitors with cardiac …