Plastics are everywhere in our modern way of living, and their production keeps increasing
every year, causing major environmental concerns. Nowadays, the end-of-life management …

Over the past ten years, scientific and technological advances have established biocatalysis
as a practical and environmentally friendly alternative to traditional metallo-and …

Protein structure and function is determined by the arrangement of the linear sequence of
amino acids in 3D space. We show that a deep graph neural network, ProteinSolver, can …

Protein phase separation is implicated in formation of membraneless organelles, signaling
puncta and the nuclear pore. Multivalent interactions of modular binding domains and their …

Computational methods that predict protein stability changes induced by missense
mutations have made a lot of progress over the past decades. Most of the available methods …

ProThermDB is an updated version of the thermodynamic database for proteins and mutants
(ProTherm), which has∼ 31 500 data on protein stability, an increase of 84% from the …

INTRODUCTION Temperature is crucially important to life. Small temperature changes can
differentiate optimal and lethal growth conditions of living organisms. Because of the higher …

Although deep learning approaches have had tremendous success in image, video and
audio processing, computer vision, and speech recognition, their applications to three …

Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively
parallel reporter assays, test thousands of sequence variants in a single experiment. Despite …

Improving protein stability is an important goal for basic research as well as for clinical and
industrial applications but no commonly accepted and widely used strategy for efficient …