Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
FR Hirsch, M Varella-Garcia, F Cappuzzo - Oncogene, 2009 - nature.com
Epidermal growth factor receptor (EGFR) and HER2 are cell surface receptor tyrosine
kinases (TKs) that transduce growth signals through dimerization with HER family receptors …
kinases (TKs) that transduce growth signals through dimerization with HER family receptors …
Immunohistochemical markers of prognosis in non-small cell lung cancer: a review and proposal for a multiphase approach to marker evaluation
Characteristics of the tumour that affect and predict the survival outcome of patients with
cancer are prognostic markers for cancer. In non-small cell lung carcinoma (NSCLC), stage …
cancer are prognostic markers for cancer. In non-small cell lung carcinoma (NSCLC), stage …
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
W Scheuer, T Friess, H Burtscher, B Bossenmaier… - Cancer research, 2009 - AACR
The human epidermal growth factor receptor (HER) family plays an important role in cell
survival and proliferation, and is implicated in oncogenesis. Overexpression of HER2 is …
survival and proliferation, and is implicated in oncogenesis. Overexpression of HER2 is …
Increased HER2 Gene Copy Number Is Associated With Response to Gefitinib Therapy in Epidermal Growth Factor Receptor–Positive Non–Small-Cell Lung Cancer …
F Cappuzzo, M Varella-Garcia… - Journal of clinical …, 2005 - ascopubs.org
Purpose In non-small-cell lung cancer (NSCLC), response to tyrosine kinase inhibitors
(TKIs) is significantly associated with the presence of increased copy number and/or …
(TKIs) is significantly associated with the presence of increased copy number and/or …
[HTML][HTML] Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus
U Reichelt, P Duesedau, MC Tsourlakis, A Quaas… - Modern Pathology, 2007 - Elsevier
HER-2 is the target for antibody based treatment of breast cancer (Herceptin®). In order to
evaluate the potential role of such a treatment in esophageal cancers, HER-2 amplification …
evaluate the potential role of such a treatment in esophageal cancers, HER-2 amplification …
Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus
F Walker, L Abramowitz, D Benabderrahmane, X Duval… - Human pathology, 2009 - Elsevier
High prevalence of squamous anal lesions is linked to oncogenic human papillomavirus
(HPV). Human immunodeficiency virus (HIV) promotes anal carcinogenesis. Epidermal …
(HPV). Human immunodeficiency virus (HIV) promotes anal carcinogenesis. Epidermal …
[HTML][HTML] The role of human epidermal growth factor receptor 2 as a prognostic factor in lung cancer: a meta-analysis of published data
L Liu, X Shao, W Gao, J Bai, R Wang, P Huang… - Journal of Thoracic …, 2010 - Elsevier
Introduction Human epidermal growth factor receptor 2 (HER2) is regarded as a poor
prognostic factor in many tumors. Conflicting data in many literatures were reported about …
prognostic factor in many tumors. Conflicting data in many literatures were reported about …
Impact of insulin-like growth factor type 1 receptor, epidermal growth factor receptor, and HER2 expressions on outcomes of patients with gastric cancer
J Matsubara, Y Yamada, Y Hirashima, D Takahari… - Clinical cancer …, 2008 - AACR
Purpose: Expression levels of insulin-like growth factor type 1 receptor (IGF-IR), epidermal
growth factor receptor (EGFR), and HER2 expressions have been linked to clinical …
growth factor receptor (EGFR), and HER2 expressions have been linked to clinical …
EGFR and erbB2 mutation status in Japanese lung cancer patients
H Sasaki, S Shimizu, K Endo, M Takada… - … journal of cancer, 2006 - Wiley Online Library
Much evidence has accumulated that the epidermal growth factor receptor (EGFR) and its
family members are strongly implicated in the development and progression of lung cancers …
family members are strongly implicated in the development and progression of lung cancers …
Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis
H Nakamura, N Kawasaki, M Taguchi, K Kabasawa - Thorax, 2006 - thorax.bmj.com
Background: It is thought that overexpression of epidermal growth factor receptor (EGFR) in
non-small cell lung cancer (NSCLC) might compromise patient survival, presumably by …
non-small cell lung cancer (NSCLC) might compromise patient survival, presumably by …