[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Preeclampsia as modulator of offspring health
V Stojanovska, SA Scherjon, T Plösch - Biology of reproduction, 2016 - academic.oup.com
A balanced intrauterine homeostasis during pregnancy is crucial for optimal growth and
development of the fetus. The intrauterine environment is extremely vulnerable to …
development of the fetus. The intrauterine environment is extremely vulnerable to …
[HTML][HTML] DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
We have developed a mouse DNA methylation array that contains 296,070 probes
representing the diversity of mouse DNA methylation biology. We present a mouse …
representing the diversity of mouse DNA methylation biology. We present a mouse …
Phase separation drives X-chromosome inactivation: a hypothesis
The long non-coding RNA Xist induces heterochromatinization of the X chromosome by
recruiting repressive protein complexes to chromatin. Here we gather evidence, from the …
recruiting repressive protein complexes to chromatin. Here we gather evidence, from the …
[HTML][HTML] LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis
T Peng, M Liu, L Hu, D Guo, D Wang, B Qi, G Ren… - Biology Direct, 2022 - Springer
Background Cardiac fibrosis is a leading cause of cardiac dysfunction in patients with
diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear. This …
diabetes. However, the underlying mechanisms of cardiac fibrosis remain unclear. This …
Reduced lncRNA Aim enhances the malignant invasion of triple-negative breast cancer cells mainly by activating Wnt/β-catenin/mTOR/PI3K signaling
L Liu, D Yu, H Shi, J Li, L Meng - Die Pharmazie-An …, 2017 - ingentaconnect.com
Increasing evidence has suggested the important role of lncRNAs in the progression of triple-
negative breast cancer (TNBC). In the current study, we first demonstrated that the …
negative breast cancer (TNBC). In the current study, we first demonstrated that the …
Transition of inner cell mass to embryonic stem cells: mechanisms, facts, and hypotheses
Embryonic stem cells (ESCs) are immortal stem cells that own multi-lineage differentiation
potential. ESCs are commonly derived from the inner cell mass (ICM) of pre-implantation …
potential. ESCs are commonly derived from the inner cell mass (ICM) of pre-implantation …
[HTML][HTML] The role of long non-coding rnas in human imprinting disorders: prospective therapeutic targets
T Wang, J Li, L Yang, M Wu, Q Ma - Frontiers in Cell and …, 2021 - frontiersin.org
Genomic imprinting is a term used for an intergenerational epigenetic inheritance and
involves a subset of genes expressed in a parent-of-origin-dependent way. Imprinted genes …
involves a subset of genes expressed in a parent-of-origin-dependent way. Imprinted genes …
[HTML][HTML] Epigenetics: A key paradigm in reproductive health
N Bunkar, N Pathak, NK Lohiya… - Clinical and Experimental …, 2016 - ncbi.nlm.nih.gov
It is well established that there is a heritable element of susceptibility to chronic human
ailments, yet there is compelling evidence that some components of such heritability are …
ailments, yet there is compelling evidence that some components of such heritability are …
[HTML][HTML] Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts
Abstract Background Mitochondrial DNA (mtDNA) copy number in oocytes correlates with
oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA …
oocyte quality and fertilisation outcome. The introduction of additional copies of mtDNA …