High levels of fasting circulating triglycerides (TG) represent an independent risk factor for
cardiovascular disease. In western countries, however, people spend most time in …

Rheumatoid arthritis (RA) associates with excess cardiovascular morbidity and mortality,
resulting in significantly shortened lifespan. Traditional risk factors (eg dyslipidaemia and …

Aims Elevated non-fasting triglycerides mark elevated levels of remnant cholesterol. Using a
Mendelian randomization approach, we tested whether genetically increased remnant …

Asians are more susceptible to type 2 diabetes mellitus (T2D) and its coronary heart disease
(CHD) complications than the Western populations, possibly due to genetic factors, higher …

Genetic variability at the APOA1/C3/A4/A5 cluster has been examined in relation to lipid
metabolism and cardiovascular disease risk. However, the findings are inconsistent. This is …

Diet is an important environmental factor interacting with our genes to modulate the
likelihood of developing lipid disorders and, consequently, cardiovascular disease risk. Our …

Obesity is currently considered a serious public health issue due to its strong impact on
health, economy, and quality of life. It is considered a chronic low‐grade inflammation state …

Mutations in the APOA5 gene, leading to truncated apolipoprotein AV devoid of lipid-binding
domains located in the carboxy-terminal end of the protein, if present in the homozygous …

Statins represent a major advance in the treatment of hypercholesterolemia, a significant risk
factor for atherosclerosis. There is, however, notable interindividual variation in the …

OBJECTIVES: The aim of the study was to identify gene polymorphisms that confer
susceptibility to metabolic syndrome in order to allow reliable assessment of genetic risk for …