[HTML][HTML] Overview of dual-acting drug methotrexate in different neurological diseases, autoimmune pathologies and cancers
P Koźmiński, PK Halik, R Chesori… - International journal of …, 2020 - mdpi.com
Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively
used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune …
used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune …
[HTML][HTML] The therapeutic landscape of rheumatoid arthritis: current state and future directions
S Shams, JM Martinez, JRD Dawson, J Flores… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …
emotional and socioeconomic consequences. Despite advances in targeted biologic and …
Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases
BN Cronstein, M Sitkovsky - Nature Reviews Rheumatology, 2017 - nature.com
Adenosine, a nucleoside derived primarily from the extracellular hydrolysis of adenine
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …
nucleotides, is a potent regulator of inflammation. Adenosine mediates its effects on …
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
[HTML][HTML] Regulation of inflammation by adenosine
G Haskó, B Cronstein - Frontiers in immunology, 2013 - frontiersin.org
Adenosine, a purine nucleoside generated by the dephosphorylation of adenine
nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many …
nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many …
Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
MJL Bours, ELR Swennen, F Di Virgilio… - Pharmacology & …, 2006 - Elsevier
Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …
The immune system is occupied with protecting the host against such dangers in order to …
Purinergic signaling and blood vessels in health and disease
G Burnstock, V Ralevic - Pharmacological reviews, 2014 - ASPET
Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …
Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
J Vinten-Johansen - Cardiovascular research, 2004 - academic.oup.com
Neutrophils respond to myocardial ischemia–reperfusion in a manner similar to the bacterial
invasion of a host. The inflammatory-like response that follows the onset of reperfusion …
invasion of a host. The inflammatory-like response that follows the onset of reperfusion …
Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury
DN Granger - American Journal of Physiology-Heart and …, 1988 - journals.physiology.org
In this lecture, evidence is presented to support the following hypothesis regarding the roles
of xanthine oxidase-derived oxidants and granulocytes in ischemia-reperfusion-induced …
of xanthine oxidase-derived oxidants and granulocytes in ischemia-reperfusion-induced …
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors
MV Sitkovsky, D Lukashev, S Apasov… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract Immune cell–mediated destruction of pathogens may result in excessive collateral
damage to normal tissues, and the failure to control activated immune cells may cause …
damage to normal tissues, and the failure to control activated immune cells may cause …