[HTML][HTML] Structures, functions and adaptations of the human LINE-1 ORF2 protein
ET Baldwin, T van Eeuwen, D Hoyos, A Zalevsky… - Nature, 2024 - nature.com
Abstract The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
around one-third of the human genome through a 'copy and paste'mechanism catalysed by …
[HTML][HTML] Separable structural requirements for cDNA synthesis, nontemplated extension, and template jumping by a non-LTR retroelement reverse transcriptase
SC Pimentel, HE Upton, K Collins - Journal of Biological Chemistry, 2022 - ASBMB
Broad evolutionary expansion of polymerase families has enabled specialization of their
activities for distinct cellular roles. In addition to template-complementary synthesis, many …
activities for distinct cellular roles. In addition to template-complementary synthesis, many …
[HTML][HTML] ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition
JL Goodier, H Wan, AO Soares, L Sanchez… - PLoS …, 2023 - journals.plos.org
Retrotransposons have generated about half of the human genome and LINE-1s (L1s) are
the only autonomously active retrotransposons. The cell has evolved an arsenal of defense …
the only autonomously active retrotransposons. The cell has evolved an arsenal of defense …
Ty3 and Related LTR-Retrotransposon Reverse Transcriptases
JT Miller, SFJ Le Grice - … : L1 Retrotransposons As A Source Of …, 2022 - books.google.com
With the exception that their life cycle does not involve an extracellular component, events
whereby the single-stranded RNA genome of long terminal repeat (LTR)-containing …
whereby the single-stranded RNA genome of long terminal repeat (LTR)-containing …