IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases

CM Alberini - Trends in neurosciences, 2023 - cell.com
Insulin-like growth factor 2 (IGF2) emerged as a critical mechanism of synaptic plasticity and
learning and memory. Deficits in IGF2 in the brain, serum, or cerebrospinal fluid (CSF) are …

[HTML][HTML] Insulin-like growth factor 2 as a possible neuroprotective agent and memory enhancer—its comparative expression, processing and signaling in mammalian …

A Beletskiy, E Chesnokova, N Bal - International Journal of Molecular …, 2021 - mdpi.com
A number of studies performed on rodents suggest that insulin-like growth factor 2 (IGF-2) or
its analogs may possibly be used for treating some conditions like Alzheimer's disease …

Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model

V Labrie, R Fukumura, A Rastogi, LJ Fick… - Human molecular …, 2009 - academic.oup.com
Abnormal N-methyl-d-aspartate receptor (NMDAR) function has been implicated in the
pathophysiology of schizophrenia. d-serine is an important NMDAR modulator, and to …

[HTML][HTML] A 20-week program of resistance or concurrent exercise improves symptoms of schizophrenia: results of a blind, randomized controlled trial

B Andrade e Silva, RC Cassilhas, C Attux… - Revista Brasileira de …, 2015 - SciELO Brasil
Objective: To evaluate the effects of 20 weeks of resistance and concurrent training on
psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3 …

Insulin growth factor 2 (IGF2) as an emergent target in psychiatric and neurological disorders. Review

M Pardo, Y Cheng, YH Sitbon, JA Lowell… - Neuroscience …, 2019 - Elsevier
Insulin-like growth factor 2 (IGF2) is abundantly expressed in the central nervous system
(CNS). Recent evidence highlights the role of IGF2 in the brain, sustained by data showing …

[HTML][HTML] Uric acid levels in subjects with schizophrenia: a systematic review and meta-analysis

Q He, Y You, L Yu, L Yao, H Lu, X Zhou, S Wu… - Psychiatry …, 2020 - Elsevier
The association between schizophrenia (SZ) and uric acid (UA) levels has been suggested
for many years, but without solid evidence. Therefore, we conducted a systematic review …

[HTML][HTML] Protein plasma levels of the IGF signalling system are altered in major depressive disorder

C Fernández-Pereira, MA Penedo… - International Journal of …, 2023 - mdpi.com
The Insulin-like growth factor 2 (IGF-2) has been recently proven to alleviate depressive-like
behaviors in both rats and mice models. However, its potential role as a peripheral …

[HTML][HTML] Altered insulin-like growth factor-2 signaling is associated with psychopathology and cognitive deficits in patients with schizophrenia

YJ Yang, T Luo, Y Zhao, SZ Jiang, JW Xiong, JQ Zhan… - PLoS …, 2020 - journals.plos.org
Background Schizophrenia is linked with abnormal brain neurodevelopment, on which IGF-
2 (insulin-like growth factor-2) has a great impact. The purpose of this study was to assess …

[HTML][HTML] Insulin-like growth factor 2 (IGF-2) and Insulin-like growth factor binding protein 7 (IGFBP-7) are upregulated after atypical antipsychotics in Spanish …

C Fernández-Pereira, MA Penedo… - International Journal of …, 2022 - mdpi.com
Insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) have been related to
schizophrenia (SZ) due to their implication in neurodevelopment. The purpose of this study …

Metabolic syndrome in severe mental disorders

JU Ohaeri, AO Akanji - Metabolic syndrome and related disorders, 2011 - liebertpub.com
The concept of metabolic syndrome in psychiatry provides a united front for confronting a
series of metabolic changes that are predictive of cardiovascular disease (CVD) and type 2 …