Effects of saponins on lipid metabolism: A review of potential health benefits in the treatment of obesity

M Marrelli, F Conforti, F Araniti, GA Statti - Molecules, 2016 - mdpi.com
Obesity is one of the greatest public health problems. This complex condition has reached
epidemic proportions in many parts of the world, and it constitutes a risk factor for several …

Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities

NH Nguyen, TKQ Ha, JL Yang, HTT Pham… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance G. pentaphyllum, also known as Jiao-Gu-Lan, has been
used traditionally as folk remedies for many diseases, including diabetes mellitus, metabolic …

Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum

C Su, N Li, R Ren, Y Wang, X Su, F Lu, R Zong, L Yang… - Molecules, 2021 - mdpi.com
Gynostemma pentaphyllum (Thunb.) Makino (GP), also named Jiaogulan in Chinese, was
known to people for its function in both health care and disease treatment. Initially and …

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

A Mastinu, SA Bonini, M Premoli, G Maccarinelli… - Molecules, 2021 - mdpi.com
Gynostemma pentaphyllum (var. Ginpent)(GP) is a variety of Cucurbit with anti-inflammatory
and antioxidant effects in patients. In this manuscript, the main components present in the …

Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1

HS Lee, SM Lim, JI Jung, SM Kim, JK Lee, YH Kim… - Nutrients, 2019 - mdpi.com
Gynostemma pentaphyllum is widely used in Asia as a herbal medicine to treat type 2
diabetes, dyslipidemia, and inflammation. Here, we investigated the anti-obesity effect and …

A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota

Z Luo, W Xu, Y Zhang, L Di, J Shan - Pharmacological research, 2020 - Elsevier
Metabolic syndrome (MetS) is a series of symptoms including insulin resistance, obesity,
dyslipidemia, elevated fasting blood glucose levels, and hepatic steatosis. As a key criterion …

Isolated compounds from natural products with potential antidiabetic activity-a systematic review

ACM Munhoz, TS Frode - Current diabetes reviews, 2018 - benthamdirect.com
Background: Worldwide, Type 2 diabetes has become a growing health problem. While
many research articles in the field of ethnopharmacology have focused on the antidiabetic …

Caco-2 Cell Permeability of Flavonoids and Saponins from Gynostemma pentaphyllum: the Immortal Herb

I Ahmed, DN Leach, H Wohlmuth, JJ De Voss… - ACS …, 2020 - ACS Publications
Gynostemma pentaphyllum (the immortal herb) has been an important component of
Chinese Traditional Medicine for millennia. Recent clinical studies have revealed that the …

Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): A randomized, double‐blind, placebo‐controlled trial

SH Park, TL Huh, SY Kim, MR Oh… - …, 2014 - Wiley Online Library
Objective The effects of actiponin was investigated, a heat‐processed Gynostemma
pentaphyllum extract, on body weight, fat loss, and metabolic markers of Korean participants …

Dammarane-type saponins from Gynostemma pentaphyllum and their anti-aging activities via up-regulating mitochondria related proteins

HZ Liang, PX Lu, LL Chu, G Li, CB Li, XJ Chen… - Phytochemistry, 2023 - Elsevier
The importance of mitochondria in regulation of aging has been extensively recognized and
confirmed. Gynostemma pentaphyllum (Thunb.) Makino, a homology of medicine and food …