CSF1R-dependent macrophages in the salivary gland are essential for epithelial regeneration after radiation-induced injury

JG McKendrick, GR Jones, SS Elder, E Watson… - Science …, 2023 - science.org
The salivary glands often become damaged in individuals receiving radiotherapy for head
and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their …

Identifying fibrogenic cells following salivary gland obstructive injury

AL Altrieth, KJ O'Keefe, VA Gellatly… - Frontiers in cell and …, 2023 - frontiersin.org
Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue
architecture and impedes function. In the salivary gland, fibrosis can be induced by …

Immunomodulation of salivary gland function due to cancer therapy

AC Costa‐da‐Silva, CU Villapudua, MP Hoffman… - Oral …, 2024 - Wiley Online Library
Functional salivary glands (SG) are essential for maintaining oral health, and salivary
dysfunction is a persistent major clinical challenge. Several cancer therapies also have off …

Retroductal dexamethasone administration promotes the recovery from obstructive and inflammatory salivary gland dysfunction

S Hwang, JM Cho, YJ Yoon, S Seo, Y Hong… - Frontiers in …, 2024 - frontiersin.org
Introduction Salivary gland dysfunction, often resulting from salivary gland obstruction-
induced inflammation, is a prevalent condition. Corticosteroid, known for its anti …

Impaired autophagy‐mediated macrophage polarization contributes to age‐related hyposalivation

Z Xin, R Xu, Y Dong, S Jin, X Ge, X Shen… - Cell …, 2024 - Wiley Online Library
Age‐related dysfunction of salivary glands (SGs) leading to xerostomia or dry mouth is
typically associated with increased dental caries and difficulties in mastication, deglutition or …

Unveiling a unique macrophage population in exocrine glands sustained by ILC2-derived GM-CSF

F Westermann, S Tuzlak, V Kreiner, D Bejarano… - bioRxiv, 2024 - biorxiv.org
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has a non-redundant role in
the emergence and maintenance of alveolar macrophages (AMs). However, its role in …