Abstract B-cell lymphoma 2 (BCL2) proteins are important cell death regulators, whose main
function is to control the release of cytochrome c from mitochondria in the intrinsic apoptotic …

The Bcl-2 family members rigorously regulate cell endogenous apoptosis, and targeting anti-
apoptotic members is a hot topic in design of anti-cancer drugs. At present, FDA and EMA …

Troubling disparities in COVID-19–associated mortality emerged early, with nearly 70% of
deaths confined to Black/African American (AA) patients in some areas. However, targeted …

Neutrophil granulocytes are innate effector cells of the first line of defense against pyogenic
bacteria. Neutrophil lifespan is short, is prolonged by pro-inflammatory stimuli, controls …

BFL-1 is an understudied pro-survival BCL-2 protein. The expression of BFL-1 is reported in
many cancers, but it is yet to be clarified whether high transcript expression also always …

Background Although anti-apoptotic proteins of the B-cell lymphoma-2 (BCL2) family have
been utilized as therapeutic targets in acute myeloid leukaemia (AML), their complicated …

C-type lectin domain family 5, member A (CLEC5A), also known as myeloid DNAX activation
protein 12 (DAP12)-associating lectin-1 (MDL-1), is a cell surface receptor strongly …

The function of the anti-apoptotic Bcl-2 family member Bcl2a1/Bfl-1/A1 is poorly understood
due to the lack of appropriate loss-of-function mouse models and redundant effects with …

Background: Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long
noncoding RNAs (lncRNAs) play key roles in drug resistance. Materials & methods: LncRNA …

The transcription factor PU. 1 is a master regulator of myeloid differentiation and function. On
the other hand, only scarce information is available on PU. 1-regulated genes involved in …