Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

MICA and MICB are expressed by many human cancers as a result of cellular stress, and
can tag cells for elimination by cytotoxic lymphocytes through natural killer group 2D …

Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

Multiple myeloma is an incurable cancer characterized by the uncontrolled growth of
malignant plasma cells nurtured within a permissive bone marrow microenvironment. While …

NKG2D ligands are widely expressed in solid and hematologic malignancies but absent or
poorly expressed on healthy tissues. We conducted a phase I dose-escalation study to …

Avoiding immune destruction is a hallmark of cancer. Over the past few years, significant
advances have been made in understanding immune dysfunction and immunosuppression …

NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …

Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in
the bone marrow (BM). Despite the significant advances in treatment, MM is still a fatal …

In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …