Neuroprotective effect of SGLT2 inhibitors

A Pawlos, M Broncel, E Woźniak, P Gorzelak-Pabiś - Molecules, 2021 - mdpi.com
Patients with diabetes are at higher risk of cardiovascular diseases and cognitive
impairment. SGLT2 inhibitors (Empagliflozin, Canagliflozin, Dapagliflozin, Ertugliflozin …

[HTML][HTML] Cognitive impairment and type 2 diabetes mellitus: Focus of SGLT2 inhibitors treatment

MR Rizzo, I Di Meo, R Polito, MC Auriemma… - Pharmacological …, 2022 - Elsevier
Gliflozins are a novel class of oral anti-diabetic drugs, acting as inhibitors of sodium-glucose
co-transporters (SGLTs) through the proximal convoluted tubules (PCT) and intestinal …

Alzheimer's disease: Novel targets and investigational drugs for disease modification

JL Cummings, AML Osse, JW Kinney - Drugs, 2023 - Springer
Novel agents addressing non-amyloid, non-tau targets in Alzheimer's Disease (AD)
comprise 70% of the AD drug development pipeline of agents currently in clinical trials. Most …

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

S Alford, D Patel, N Perakakis, CS Mantzoros - Obesity reviews, 2018 - Wiley Online Library
Alzheimer's disease (AD) is the sixth leading cause of death in the USA today; therefore, it is
imperative that public health initiatives and clinical strategies are developed to prevent and …

Current and emerging avenues for Alzheimer's disease drug targets

R Loera‐Valencia, A Cedazo‐Minguez… - Journal of internal …, 2019 - Wiley Online Library
Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

Sodium-glucose cotransporter 2 (SGLT2) inhibitors vs. dipeptidyl peptidase-4 (DPP4) inhibitors for new-onset dementia: a propensity score-matched population …

JV Mui, J Zhou, S Lee, KSK Leung, TTL Lee… - Frontiers in …, 2021 - frontiersin.org
Introduction: The effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) and
dipeptidyl peptidase-4 inhibitors (DPP4I) on new-onset cognitive dysfunction in type 2 …

Empagliflozin reduces vascular damage and cognitive impairment in a mixed murine model of Alzheimer's disease and type 2 diabetes

C Hierro-Bujalance, C Infante-Garcia… - Alzheimer's research & …, 2020 - Springer
Abstract Background Both Alzheimer's disease (AD) and type 2 diabetes (T2D) share
common pathological features including inflammation, insulin signaling alterations, or …

Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case–control study

IK Wium-Andersen, M Osler… - European journal of …, 2019 - academic.oup.com
Objective Diabetes is a risk factor for dementia, but whether antidiabetic medication
decreases the risk is unclear. We examined the association between antidiabetic medication …

Unlocking the full potential of SGLT2 inhibitors: expanding applications beyond glycemic control

ME Youssef, G Yahya, MS Popoviciu, S Cavalu… - International Journal of …, 2023 - mdpi.com
The number of diabetic patients has risen dramatically in recent decades, owing mostly to
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …

Newer glucose‐lowering drugs and risk of dementia: a systematic review and meta‐analysis of observational studies

H Tang, H Shao, CE Shaaban, K Yang… - Journal of the …, 2023 - Wiley Online Library
Background Preclinical studies have suggested potential beneficial effects of newer glucose‐
lowering drugs (GLDs) including dipeptidyl peptidase (DPP)‐4 inhibitors, glucagon‐like …