Oxidative stress and regeneration

M Jaganjac, L Milkovic, N Zarkovic… - Free Radical Biology and …, 2022 - Elsevier
Regeneration is the process of replacing/restoring a damaged cell/tissue/organ to its full
function and is limited respecting complexity of specific organ structures and the level of …

Casting a wide net: role of perineuronal nets in neural plasticity

BA Sorg, S Berretta, JM Blacktop… - Journal of …, 2016 - Soc Neuroscience
Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain
neurons in the CNS during development and control plasticity in the adult CNS. They appear …

Formation and remodeling of the brain extracellular matrix in neural plasticity: Roles of chondroitin sulfate and hyaluronan

S Miyata, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2017 - Elsevier
Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

[HTML][HTML] Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

S Yang, S Gigout, A Molinaro, Y Naito-Matsui… - Molecular …, 2021 - nature.com
Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on
the neuronal surface that have been implicated in the control of neuroplasticity and memory …

Perineuronal nets in brain physiology and disease

D Testa, A Prochiantz, AA Di Nardo - Seminars in cell & developmental …, 2019 - Elsevier
Perineuronal nets (PNNs) in the brain are condensed glycosaminoglycan-rich extracellular
matrix structures with heterogeneous composition yet specific organization. They typically …

[HTML][HTML] Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

S Foscarin, R Raha-Chowdhury, JW Fawcett… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous
system (CNS) are involved in the control of plasticity and memory. Removing PNNs …

The mechanisms of perineuronal net abnormalities in contributing aging and neurological diseases

Y Dong, K Zhao, X Qin, G Du, L Gao - Ageing Research Reviews, 2023 - Elsevier
The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

“GAG-ing with the neuron”: the role of glycosaminoglycan patterning in the central nervous system

PD Smith, VJ Coulson-Thomas, S Foscarin… - Experimental …, 2015 - Elsevier
Proteoglycans (PGs) are a diverse family of proteins that consist of one or more
glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are major …

[HTML][HTML] HS, an ancient molecular recognition and information storage glycosaminoglycan, equips hs-proteoglycans with diverse matrix and cell-interactive properties …

AJ Hayes, J Melrose - International Journal of Molecular Sciences, 2023 - mdpi.com
Heparan sulfate is a ubiquitous, variably sulfated interactive glycosaminoglycan that
consists of repeating disaccharides of glucuronic acid and glucosamine that are subject to a …

Proteolytic remodeling of perineuronal nets: effects on synaptic plasticity and neuronal population dynamics

P Lorenzo Bozzelli, S Alaiyed, E Kim, S Villapol… - Neural …, 2018 - Wiley Online Library
The perineuronal net (PNN) represents a lattice‐like structure that is prominently expressed
along the soma and proximal dendrites of parvalbumin‐(PV‐) positive interneurons in varied …